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(R)-(+)-Carvedilol

Names

[ CAS No. ]:
95093-99-5

[ Name ]:
(R)-(+)-Carvedilol

[Synonym ]:
(R)-(+)-Carvedilol
S-(-)-1-(carbazol-4-yloxy)-3-[[2-(O-methoxyphenoxy)ethyl]amino]-2-propanol
(S)-carvedilol
(+)-Carvedilol
Carvedilol Impurity 10

Biological Activity

[Description]:

(R)-Carvedilol ((R)-BM 14190), the R-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

β/α-1 adrenergic receptor[1]


[References]

[1]. Wu T, et al. Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244.

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Boiling Point ]:
655.2ºC at 760 mmHg

[ Melting Point ]:
114-115ºC

[ Molecular Formula ]:
C24H26N2O4

[ Molecular Weight ]:
406.47400

[ Flash Point ]:
350.1ºC

[ Exact Mass ]:
406.18900

[ PSA ]:
75.74000

[ LogP ]:
4.12890

[ Index of Refraction ]:
1.657

[ Storage condition ]:
2-8°C

Related Compounds