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Fosinoprilat

Names

[ CAS No. ]:
95399-71-6

[ Name ]:
Fosinoprilat

[Synonym ]:
forsythiaside
forsytoside A
forsythoside
FOSINOPRILAT
Forsythiaside A

Biological Activity

[Description]:

Fosfenopril is a potent angiotensin converting enzyme (ACE) inhibitor. Fosfenopril alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-κB signaling in monocytes[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Research Areas >> Inflammation/Immunology

[Target]

TLR4

NF-κB


[References]

[1]. Yang S, et al. Fosinoprilat alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-κB signaling in monocytes. Cell Immunol. 2013 Jul-Aug;284(1-2):182-6.

[2]. DeForrest JM, et al. Fosinopril, a phosphinic acid inhibitor of angiotensin I converting enzyme: in vitro and preclinical in vivo pharmacology. J Cardiovasc Pharmacol. 1989 Nov;14(5):730-6.

Chemical & Physical Properties

[ Density]:
1.238g/cm3

[ Boiling Point ]:
728.9ºC at 760mmHg

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C23H34NO5P

[ Molecular Weight ]:
435.49400

[ Flash Point ]:
394.6ºC

[ Exact Mass ]:
435.21700

[ PSA ]:
104.72000

[ LogP ]:
4.09960

[ Index of Refraction ]:
1.564

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds