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H-Gly-Gly-Cys-OH

Names

[ CAS No. ]:
95416-30-1

[ Name ]:
H-Gly-Gly-Cys-OH

[Synonym ]:
Glycyl-glycyl-cysteine
Gly-gly-cys

Biological Activity

[Description]:

Glycylglycylcysteine is a Thrombin Activatable Fibrinolysis Inhibitor (TAFI) inhibitor with a Ki of 0.99 μM and a IC50 of 9.4 μM in TAFI substrate assays. TAFI is a basic carboxypeptidase that functions as a fibrinolysis inhibitor through the cleavage of C-terminal lysine on partially degraded fibrin[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[Target]

IC50: 9.4 μM (TAFI) Ki: 0.99 μM (TAFI)[1]


[References]

[1]. Do YH, et al. Inhibition of thrombin activatable fibrinolysis inhibitor by cysteine derivatives. Thromb Res. 2005;116(3):265-71.  

Chemical & Physical Properties

[ Molecular Formula ]:
C7H13N3O4S

[ Molecular Weight ]:
235.26

[ Exact Mass ]:
235.06300

[ PSA ]:
167.30000


Related Compounds