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Propargyl-PEG-amine

Names

[ CAS No. ]:
956348-61-1

[ Name ]:
Propargyl-PEG-amine

[Synonym ]:
MFCD30723251
3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72-Tetracosaoxapentaheptacont-74-yn-1-amine

Biological Activity

[Description]:

Propargyl-PEG-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
911.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
(C2H4O)nC5H9NO

[ Molecular Weight ]:
1112.340

[ Flash Point ]:
479.1±26.6 °C

[ Exact Mass ]:
1111.671387

[ LogP ]:
-8.34

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.469

Related Compounds