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Pomaglumetad methionil

Names

[ CAS No. ]:
956385-05-0

[ Name ]:
Pomaglumetad methionil

[Synonym ]:
Pomaglumetad methionil
UNII-WE665JB15R

Biological Activity

[Description]:

Pomaglumetad methionil (LY2140023 hydrate) is an oral methionine prodrug of the potent specific mGlu2/3 receptor agonist LY404039 (HY-50906). Pomaglumetad methionil is well-tolerated and has a distinct safety profile, and can be used to treat schizophrenia[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

mGlu2/3 receptor[1][2]


[References]

[1]. Adams DH, et al. A long-term, phase 2, multicenter, randomized, open-label, comparative safety study of pomaglumetad methionil (LY2140023 monohydrate) versus atypical antipsychotic standard of care in patients with schizophrenia. BMC Psychiatry. 2013 May 22;13:143.

[2]. Downing AM, et al. A Double-Blind, Placebo-Controlled Comparator Study of LY2140023 monohydrate in patients with schizophrenia. BMC Psychiatry. 2014 Dec 10;14:351.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H20N2O8S2

[ Molecular Weight ]:
384.42600

[ Exact Mass ]:
384.06600

[ PSA ]:
210.26000

[ LogP ]:
0.69110

Related Compounds