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Bromo-PEG5-alcohol

Names

[ CAS No. ]:
957205-14-0

[ Name ]:
Bromo-PEG5-alcohol

[Synonym ]:
14-Bromo-3,6,9,12-tetraoxatetradecan-1-ol
3,6,9,12-Tetraoxatetradecan-1-ol, 14-bromo-

Biological Activity

[Description]:

Bromo-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
364.6±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H21BrO5

[ Molecular Weight ]:
301.17500

[ Flash Point ]:
174.3±25.1 °C

[ Exact Mass ]:
300.05700

[ PSA ]:
57.15000

[ LogP ]:
-0.89

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.475

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds