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(+)-guajadial

Names

[ CAS No. ]:
959860-49-2

[ Name ]:
(+)-guajadial

[Synonym ]:
(2aR,4aR,10R,10aS,13aS)-7,9-Dihydroxy-2,2,4a-trimethyl-13-methylene-10-phenyl-1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydrocyclobuta[6,7]cyclonona[1,2-b]chromene-6,8-dicarbaldehyde
Benzo[b]cyclobuta[5,6]cyclonona[1,2-e]pyran-6,8-dicarboxaldehyde, 1,2,2a,3,4,4a,10,10a,11,12,13,13a-dodecahydro-7,9-dihydroxy-2,2,4a-trimethyl-13-methylene-10-phenyl-, (2aR,4aR,10R,10aS,13aS)-
guajadial

Biological Activity

[Description]:

Guajadial, a caryophyllene-based meroterpenoid, has anti-estrogenic and anticancer effect. Guajadial reverses multidrug resistance in cancer. Guajadial can be isolated from Psidium guajava leaves[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Bazioli JM, et al. Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.). Molecules. 2020 Mar 27;25(7):1525.  

[2]. Li Y, et al. Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and suppressing the PI3K/Akt pathway in drug-resistant breast cancer cells. Chem Biol Interact. 2019 May 25;305:98-104.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
518.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H34O5

[ Molecular Weight ]:
474.59

[ Flash Point ]:
160.7±23.6 °C

[ Exact Mass ]:
474.240631

[ PSA ]:
83.83000

[ LogP ]:
10.34

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.627

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds