1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol

Names

[ CAS No. ]:
968-63-8

[ Name ]:
1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol

[Synonym ]:
Butinoline

Biological Activity

[Description]:

1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is an anticholinergic agent. 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol has the potential for the research of bronchial asthma[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Heuer, Hubert, et al. Synergistic combinations of PAF antagonists and anticholinergic agents as drugs for treatment of bronchial asthma.

Chemical & Physical Properties

[ Density]:
1.139g/cm3

[ Boiling Point ]:
475.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₁NO

[ Molecular Weight ]:
291.38700

[ Flash Point ]:
247.8ºC

[ Exact Mass ]:
291.16200

[ PSA ]:
23.47000

[ LogP ]:
2.95960

[ Index of Refraction ]:
1.609

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES0779000

CHEMICAL NAME :: 2-Butyn-1-ol, 1,1-diphenyl-4-(1-pyrrolidinyl)-

CAS REGISTRY NUMBER :: 968-63-8

BEILSTEIN REFERENCE NO. :: 1388528

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H21-N-O

MOLECULAR WEIGHT :: 291.42

WISWESSER LINE NOTATION :: T5NTJ A2UU1XQR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 13,325,1965

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%