IX 207-887

Names

[ Name ]:
IX 207-887

[Synonym ]:
IX 207887
4H-Benzo[4,5]cyclohepta[1,2-b]thiophene, acetic acid deriv.
(Z)-10-METHOXY-4H-BENZO[4,5]CYCLOHEPTA[1,2-B]THIOPHENE-4-YLIDENE ACETIC ACID
Acetic acid, (10-methoxy-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-
IX 207-887

Biological Activity

[Description]:

IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1).

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

Research Areas >> Inflammation/Immunology

[Target]

Interleukin-1[1]

[In Vitro]

IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1) from human monocytes and mouse peritoneal macrophages. In all test systems IX 207-887 significantly reduces both biologically active and immunoreactive IL-1 in culture media, whereas the levels of IL-1 in homogenates or lysates are either unaffected or only marginally reduced. IX 207-887 neither affects the adherence of human monocytes nor markedly inhibits IL-1 or IL-2-induced thymocyte proliferation. In the chondrocyte test no IL-1 antagonistic activity of IX 207-887 can be observed[1].

[References]

[1]. Schnyder J, et al. Inhibition of interleukin-1 release by IX 207-887. Agents Actions. 1990 Jun;30(3-4):350-62.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂O₃S

[ Molecular Weight ]:
284.33000

[ Exact Mass ]:
284.05100

[ PSA ]:
74.77000

[ LogP ]:
3.72230

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%