N-Butanoyl-DL-homoserine lactone

Names

[ Name ]:
N-Butanoyl-DL-homoserine lactone

[Synonym ]:
MFCD018629

Biological Activity

[Description]:

N-Butanoyl-DL-homoserine lactone ((Rac)-C4-HSL) is a quorum sensing (QS) signaling molecule. N-Butanoyl-DL-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vitro]

The dissociation constant (Kd value) of aptamer binding to N-Butanoyl-DL-homoserine lactone is 28.47 nM[1].

[References]

[1]. Zhao M, et al. C4-HSL aptamers for blocking qurom sensing and inhibiting biofilm formation in Pseudomonas aeruginosa and its structure prediction and analysis. PLoS One. 2019 Feb 19;14(2):e0212041.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈H₁₃NO₃

[ Molecular Weight ]:
171.19400

[ Exact Mass ]:
171.09000

[ PSA ]:
55.40000

[ LogP ]:
0.60910

[ Storage condition ]:
2-8℃

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932209090

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones.

Microbiology 143 , 3703, (1997)

Quorum sensing relies upon the interaction of a diffusible signal molecule with a transcriptional activator protein to couple gene expression with cell population density. In Gram-negative bacteria, s...

Detection of acyl-homoserine lactones by Escherichia and Salmonella.

Curr. Opin. Microbiol. 14 , 188-193, (2011)

Escherichia and Salmonella do not synthesize quorum-sensing signaling molecules of the N-acyl-l-homoserine lactone (AHL) type but they can detect AHLs produced by other species of bacteria. AHLs are p...

N-acyl homoserinelactone-mediated gene regulation in gram-negative bacteria.

Syst. Appl. Microbiol. 22 , 493-506, (1999)

The view of bacteria as unicellular organisms has strong roots in the tradition of culturing bacteria in liquid media. However, in nature microbial activity is mainly associated with surfaces where ba...