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5,8,4'-Trihydroxy-6,7-dimethoxyflavone

Names

[ CAS No. ]:
98755-25-0

[ Name ]:
5,8,4'-Trihydroxy-6,7-dimethoxyflavone

[Synonym ]:
4H-1-Benzopyran-4-one, 5,8-dihydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-
5,8-Dihydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4H-chromen-4-one
5,8,4'-Trihydroxy-6,7-dimethoxyflavone

Biological Activity

[Description]:

Isothymusin is a potent anti-oxidant agent. Isothymusin shows radical scavenging activities. Isothymusin shows anti-proliferative activities in cancer cell lines. Isothymusin inhibited the enzymes associated with the promotion stage of cancer, including cycloxygenase- 2 and lipoxygenase-5[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[References]

[1]. Kelm MA, et al. Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine. 2000 Mar;7(1):7-13.

[2]. Singh S, et al. Isothymusin, a Potential Inhibitor of Cancer Cell Proliferation: An In Silico and In Vitro Investigation. Curr Top Med Chem. 2020;20(21):1898-1909.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
628.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H14O7

[ Molecular Weight ]:
330.29

[ Flash Point ]:
235.8±25.0 °C

[ Exact Mass ]:
330.073944

[ PSA ]:
109.36000

[ LogP ]:
0.83

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.671

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds