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Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt

Names

[ CAS No. ]:
98992-65-5

[ Name ]:
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt

[Synonym ]:
Glycine, N-[(2S)-2-[[2-[[(2S)-2-[[[(2S)-1-acetyl-2-pyrrolidinyl]carbonyl]amino]-4-methyl-1-oxopentyl]amino]acetyl]thio]-4-methyl-1-oxopentyl]-L-leucyl-, ethyl ester
Ethyl N-{(2S)-2-[(1-acetyl-L-prolyl-L-leucylglycyl)sulfanyl]-4-methylpentanoyl}-L-leucylglycinate

Biological Activity

[Description]:

Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate, and can be used to detect MMP12 enzyme activity[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[References]

[1]. Dong XW, et al. Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles. Eur J Med Chem. 2019 Feb 15;164:602-614.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
893.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C31H53N5O8S

[ Molecular Weight ]:
655.846

[ Flash Point ]:
494.3±34.3 °C

[ Exact Mass ]:
655.361511

[ PSA ]:
205.38000

[ LogP ]:
4.10

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.517

Related Compounds