<Suppliers Price>

Nebivolol

Names

[ CAS No. ]:
99200-09-6

[ Name ]:
Nebivolol

[Synonym ]:
Nebivolol
MFCD00865796
(S,R,R,R)-NEBIVOLOL-D2,15N HYDROCHLORIDE
Nibivolol
rac-nebivolol
NEBIVOLOLHCL
NEBIVOLOL HYDROCHLORIDE
NEBIVOLOL-D4

Biological Activity

[Description]:

(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

IC50: 0.8 nM (β1-adrenergic receptor)[1]


[In Vivo]

Nebivolol (10 mg/kg; daily for 7 days) markedly improves endothelial dysfunction and increases P-VASP levels; prevents NOS III uncoupling; significantly inhibit NADPH oxidase in Angiotensin II-treated rats[3].

[References]

[1]. do Vale GT, et al. Nebivolol Prevents Up-Regulation of Nox2/NADPH Oxidase and Lipoperoxidation in the Early Stages of Ethanol-Induced Cardiac Toxicity. Cardiovasc Toxicol. 2021 Mar;21(3):224-235.

[2]. Cockcroft JR, et al. Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine/NO-dependent mechanism. J Pharmacol Exp Ther. 1995 Sep;274(3):1067-71.

[3]. Oelze M, et al. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension. 2006 Oct;48(4):677-84.

Chemical & Physical Properties

[ Density]:
1.309 g/cm3

[ Boiling Point ]:
600.5ºC at 760 mmHg

[ Melting Point ]:
155-156°C(lit.)

[ Molecular Formula ]:
C22H25F2NO4

[ Molecular Weight ]:
405.43500

[ Flash Point ]:
316.9ºC

[ Exact Mass ]:
405.17500

[ PSA ]:
70.95000

[ LogP ]:
2.75450

[ Index of Refraction ]:
1.58

[ Storage condition ]:
20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds