Alkynyl Palmitic Acid

Names

[ CAS No. ]:
99208-90-9

[ Name ]:
Alkynyl Palmitic Acid

[Synonym ]:
15-Hexadecyanoic acid
15-Hexadecynoic acid
15-Hexadecyn-1-oic acid

Biological Activity

[Description]:

Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
371.8±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₈O₂

[ Molecular Weight ]:
252.392

[ Flash Point ]:
180.7±15.1 °C

[ Exact Mass ]:
252.208923

[ PSA ]:
37.30000

[ LogP ]:
5.80

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.470

Safety Information

[ HS Code ]:
2916190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%