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RO 19-4603

Names

[ CAS No. ]:
99632-94-7

[ Name ]:
RO 19-4603

[Synonym ]:
Tocris-1995

Biological Activity

[Description]:

Ro19-4603 is a benzodiazepine inverse agonist. Ro19-4603 antagonizes ethanol (EtOH) intake in alcohol-preferring rats[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vivo]

Ro19-4603 (0-0.3 mg/kg，腹腔注射) 显着降低嗜酒大鼠在 8 小时间隔内的乙醇摄入量[1]。 Animal Model: Alcohol-Preferring rats[1] Dosage: 0.075, 0.150, and 0.30 mg/kg. Administration: i.p. Result: Reduced EtOH intake at the 8-h interval, but no apparent effect at the 24-h interval.

[References]

[1]. June HL, et al. The benzodiazepine inverse agonist RO19-4603 exerts prolonged and selective suppression of ethanol intake in alcohol-preferring (P) rats. Psychopharmacology (Berl). 1994 Jul;115(3):325-31.  

Chemical & Physical Properties

[ Density]:
1.37g/cm3

[ Boiling Point ]:
537.7ºC at 760 mmHg

[ Molecular Formula ]:
C15H17N3O3S

[ Molecular Weight ]:
319.38

[ Flash Point ]:
279ºC

[ Exact Mass ]:
319.09900

[ PSA ]:
92.67000

[ LogP ]:
2.41260

[ Index of Refraction ]:
1.659

Related Compounds