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Scholaricine

Names

[ CAS No. ]:
99694-90-3

[ Name ]:
Scholaricine

[Synonym ]:
Curan-17-oic acid, 2,16-didehydro-12,19-dihydroxy-, methyl ester, (19S)-
Methyl (19S)-12,19-dihydroxy-2,16-didehydrocuran-17-oate

Biological Activity

[Description]:

Scholaricine (compound 13 ) is an alkaloid isolated from the leaf and stem-bark extracts of Alstonia spatulata. Scholaricine reverse multidrug resistance in vincristine-resistant KB cells with an IC50 value of 13.35 μM[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Shin-Jowl Tan , et al. Strychnan and secoangustilobine A type alkaloids from Alstonia spatulata. Revision of the C-20 configuration of scholaricine. J Nat Prod. 2010, 73, 11.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
519.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H24N2O4

[ Molecular Weight ]:
356.42

[ Flash Point ]:
268.0±30.1 °C

[ Exact Mass ]:
356.173615

[ PSA ]:
82.03000

[ LogP ]:
1.41

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.684

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds