mGluR2 modulator 3

Names

[ CAS No. ]:
1004614-58-7

[ Name ]:
mGluR2 modulator 3

Biological Activity

[Description]:

mGluR2 modulator 3 (compound 1) is a potent mGluR2 positive allosteric modulator with an EC50 value of 0.87 μM. mGluR2 modulator 3 has activity in psychosis disease models such as methamphetamine-induced hyperactivity and mescaline-induced scratching in mice[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

mGluR2:0.87 μM (EC50)


[References]

[1]. Szabó G, et al. Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs). Eur J Med Chem. 2020;186:111881.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H25N3O

[ Molecular Weight ]:
335.44

Related Compounds