PKI (5-24),amide

Names

[ CAS No. ]:
100891-36-9

[ Name ]:
PKI (5-24),amide

Biological Activity

[Description]:

PKI (5-24),amide (IP20-amide) is a 20-residue peptide that corresponds to the active portion of the heat-stable inhibitor protein of cAMP-dependent protein kinase. PKI (5-24),amide is a potent cAMP-dependent protein kinase (PKA) (PKA) inhibitor with a Ki of 2.3 nM[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA
Signaling Pathways >> Stem Cell/Wnt >> PKA
Research Areas >> Neurological Disease

[References]

[1]. D B Glass, et al. Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein. J Biol Chem. 1989 May 25;264(15):8802-10.  

Chemical & Physical Properties

[ Molecular Formula ]:
C94H149N33O30

[ Molecular Weight ]:
2221.40

Related Compounds