Risedronic Acid-d4

Names

[ CAS No. ]:
1035438-80-2

[ Name ]:
Risedronic Acid-d4

[Synonym ]:
risedronic acid-d4
Risedronic acid-d4

Biological Activity

[Description]:

Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid. Risedronic acid (Risedronate) is a pyridinyl biphosphonate which inhibits osteoclast-mediated bone resorption[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Giljevic Z, et al. Treatment of osteoporosis by risedronate-- speed, efficacy and safety. Reumatizam. 2006;53(2):66-71.

[3]. Jordao FM, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31.

Chemical & Physical Properties

[ Molecular Formula ]:
C7H7D4NO7P2

[ Molecular Weight ]:
287.13700

[ Exact Mass ]:
287.02600

[ PSA ]:
167.80000

Related Compounds