BiCAPPA

Names

[ CAS No. ]:
119662-55-4

[ Name ]:
BiCAPPA

[Synonym ]:
BiCAPPA
N,N inverted exclamation marka-Bis(6-chloro-2-methoxy-9-acridinyl)-1,4-piperazinedipropanamine
N,N'-Bis(6-chloro-2-methoxy-9-acridinyl)-1,4-piperazinedipropanamine

Biological Activity

[Description]:

BiCAPPA is the first bivalent antiprion ligand. BiCAPPA can decrease infectious conformational form of prion protein (PrPSc) from scrapie-infected cells, with an EC50 of 0.32 μM[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vitro]

BiCAPPA (10 nM-2 μM; 5 d) 降低感染痒病的小鼠下丘脑细胞的蛋白酶 K 抗性 PrPSc，EC50 值为 0.32 μM [2]。

[References]

[1]. Uliassi E, et, al. 10-Medicinal Chemistry of Hybrids for Neurodegenerative Diseases. Design of Hybrid Molecules for Drug Development. 2017, Pages 259-277.

[2]. Bongarzone S, et, al. Parallel synthesis, evaluation, and preliminary structure-activity relationship of 2,5-diamino-1,4-benzoquinones as a novel class of bivalent anti-prion compound. J Med Chem. 2010 Nov 25;53(22):8197-201.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₈H₄₀Cl₂N₆O₂

[ Molecular Weight ]:
683.66900

[ Exact Mass ]:
682.25900

[ PSA ]:
81.24000

[ LogP ]:
7.05480

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

Articles

Protein aggregation and neurodegenerative disease.

Nat. Med. 10 Suppl , S10-S17 , (2004)

Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are increasingly being realized...

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines.

Proc. Natl. Acad. Sci. U. S. A. 100 , 3416-3421, (2003)

Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds aga...