D-(-)-4-Hydroxyphenyl-d4-glycine

Names

[ CAS No. ]:
1217854-79-9

[ Name ]:
D-(-)-4-Hydroxyphenyl-d4-glycine

[Synonym ]:
(2R)-2-amino-2-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)acetic acid

Biological Activity

[Description]:

D-4-Hydroxyphenylglycine-d4 (D-(-)-4-Hydroxyphenylglycine-d4) is the deuterium labeled D-4-Hydroxyphenylglycine. D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190)[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Yu H, et al. Efficient biocatalytic production of D-4-hydroxyphenylglycine by whole cells of recombinant Ralstonia pickettii. Folia Microbiol (Praha). 2009;54(6):509-515.

Chemical & Physical Properties

[ Molecular Formula ]:
C8H5D4NO3

[ Molecular Weight ]:
171.18700

[ Exact Mass ]:
171.08300

[ PSA ]:
83.55000

[ LogP ]:
1.17690

Related Compounds