Dimethyl biphenyl-4,4'-dicarboxylate-d8

Names

[ CAS No. ]:
1219803-50-5

[ Name ]:
Dimethyl biphenyl-4,4'-dicarboxylate-d8

[Synonym ]:
[1,1'-Biphenyl-d]-4,4'-dicarboxylic acid, dimethyl ester
Dimethyl 4,4'-(H)biphenyldicarboxylate
Dimethyl (H)biphenyl-4,4'-dicarboxylate

Biological Activity

[Description]:

Dimethyl biphenyl-4,4'-dicarboxylate-d8 is the deuterium labeled Dimethyl biphenyl-4,4'-dicarboxylate[1]. Dimethyl biphenyl-4,4'-dicarboxylate (Biphenyl dimethyl dicarboxylate) is a hepatoprotectant obtained from Schizandra fructus and may induce a signal transduction similar to that associated with IFN[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Joo SS, et al. Interferon signal transduction of biphenyl dimethyl dicarboxylate/amantadine and anti-HBV activity in HepG2 2.2.15. Arch Pharm Res. 2006 May;29(5):405-11.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
407.0±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H6D8O4

[ Molecular Weight ]:
278.329

[ Flash Point ]:
204.7±25.2 °C

[ Exact Mass ]:
278.139435

[ LogP ]:
3.71

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.559

Related Compounds