Trimyristin--d15

Names

[ CAS No. ]:
1219804-94-0

[ Name ]:
Trimyristin--d15

Biological Activity

[Description]:

Trimyristin--d15 is the deuterium labeled Trimyristin. Trimyristin, an active molluscicidal component of Myristica fragrans Houtt, significantly inhibits acetylcholinesterase (AChE), acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata. IC50s of Trimyristin against AChE, ACP, and ALP are 0.11, 0.16 and 0.18 mM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Signaling Pathways >> Neuronal Signaling >> AChE

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Jaiswal P, et al. Enzyme Inhibition by Molluscicidal Components of Myristica fragrans Houtt. in the NervousTissue of Snail Lymnaea acuminata. Enzyme Res. 2010;2010:478746.

Chemical & Physical Properties

[ Molecular Formula ]:
C45H71D15O6

[ Molecular Weight ]:
738.25

Related Compounds