ADR 851

Names

[ Name ]:
ADR 851

[Synonym ]:
7-Benzofurancarboxamide,4-amino-5-chloro-2,3-dihydro-N-(2-pyrrolidinylmethyl)-,monohydrochloride,(S)
Adr 851
4-amino-5-chloro-N-[[(2S)-pyrrolidin-2-yl]methyl]-2,3-dihydro-1-benzofuran-7-carboxamide hydrochloride
4-Amino-5-chloro-N-(2-pyrrolidinylmethyl)-2,3-dihydrobenzofuran-7-carboxamide hcl

Biological Activity

[Description]:

ADR 851 is a dopamine D2 receptor antagonist,and can be used in research on antiemetics[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Monković I, et al. 7 Developments in the Antiemetic Area: Chemistry, Pharmacology and Therapy[J]. Progress in medicinal chemistry, 1990, 27: 297-323.

Chemical & Physical Properties

[ Boiling Point ]:
423.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₉Cl₂N₃O₂

[ Molecular Weight ]:
332.22600

[ Flash Point ]:
209.7ºC

[ Exact Mass ]:
331.08500

[ PSA ]:
79.87000

[ LogP ]:
3.62570

[ Vapour Pressure ]:
2.28E-07mmHg at 25°C