Metallo-β-lactamase-IN-3

Names

[ CAS No. ]:
128294-71-3

[ Name ]:
Metallo-β-lactamase-IN-3

Biological Activity

[Description]:

Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against VIM-1 and NDM-1, with IC50 of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.6 ± 0.0 μM (VIM-1), 1.0 ± 0.4 μM (NDM-1), > 10 μM (IMP-7)[1]


[References]

[1]. Kaya C, et al. N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases. J Med Chem. 2022 Mar 10;65(5):3913-3922.

Chemical & Physical Properties

[ Molecular Formula ]:
C10H11NO3S

[ Molecular Weight ]:
225.26

Related Compounds