a-FABP-IN-1

Names

[ Name ]:
a-FABP-IN-1

[Synonym ]:
compound 5g [PMID: 21481589]
2-({2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl]-3-biphenylyl}oxy)-2-methylpropanoic acid
Propanoic acid, 2-[[2'-[1-(4-chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methyl-
2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid

Biological Activity

[Description]:

a-FABP-IN-1 (Compound 5g) is a potent and selective human adipocyte fatty acid-binding protein (a-FABP) inhibitor with a Ki below 1.0 nM. a-FABP-IN-1 inhibits the pro-inflammatory cytokine production[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> FABP

[Target]

Ki: <1.0 nM (a-FABP)[1]

[References]

[1]. Liu X, et al. New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg Med Chem Lett. 2011 May 15;21(10):2949-52.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
654.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₉H₂₃ClN₂O₃S

[ Molecular Weight ]:
515.02

[ Flash Point ]:
349.5±31.5 °C

[ Exact Mass ]:
514.111816

[ LogP ]:
8.09

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.651