PF-10040

Names

[ Name ]:
PF-10040

[Synonym ]:
1-[2-(3,4-dimethoxyphenyl)ethyl]-6-methyl-3,4-dihydroisoquinoline hydrochloride
1-(2-(3,4-Dimethoxyphenyl)ethyl)-3,4-dihydro-6-methylisoquinoline hydrochloride
Isoquinoline,1-(2-(3,4-dimethoxyphenyl)ethyl)-3,4-dihydro-6-methyl-,hydrochloride
1-(3,4-Dimethoxyphenylethyl)-6-methyl-3,4-dihydroisoquinoline

Biological Activity

[Description]:

PF-10040 is a quinoline derivative that can inhibit PAF-induced airway hyperresponsiveness. PF-10040 also shows protective effect in experimental NSAID-gastritis[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Herd CM, et, al. Effect of PF 10040 on PAF-induced airway responses in neonatally immunized rabbits. Br J Pharmacol. 1994 Jan;111(1):7-12.

[2]. Wallace JL, et, al. Protective effects of PF-10040 in experimental NSAID-gastritis: role of leukocytes, leukotrienes and PAF. J Lipid Mediat. 1993 Jun;7(2):183-96.

Chemical & Physical Properties

[ Boiling Point ]:
446.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₀H₂₄ClNO₂

[ Molecular Weight ]:
345.86300

[ Flash Point ]:
179.9ºC

[ Exact Mass ]:
345.15000

[ PSA ]:
30.82000

[ LogP ]:
4.22780

[ Vapour Pressure ]:
9.68E-08mmHg at 25°C