Memantine-d3 hydrochloride

Names

[ CAS No. ]:
1329802-06-3

[ Name ]:
Memantine-d3 hydrochloride

[Synonym ]:
Tricyclo[3.3.1.13,7]decan-1-amine, 3-methyl-5-(methyl-d3)-, hydrochloride (1:1)
3-Methyl-5-(2H3)methyl-1-adamantanamine hydrochloride (1:1)

Biological Activity

[Description]:

Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD)[1][2][3].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Marotta G, et al. Memantine Derivatives as Multitarget Agents in Alzheimer's Disease. Molecules. 2020;25(17):4005. Published 2020 Sep 2.

[3]. Pinho J, et al. Enhanced LTP in aged rats: Detrimental or compensatory?. Neuropharmacology. 2017;114:12-19.

[4]. Moriguchi S, et al. Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice. Neuroscience. 2020;442:264-273.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H19D3ClN

[ Molecular Weight ]:
218.78

[ Exact Mass ]:
218.162903

Related Compounds