LY 293284

Names

[ CAS No. ]:
141318-62-9

[ Name ]:
LY 293284

[Synonym ]:
Ethanone,1-(4-(dipropylamino)-1,3,4,5-tetrahydrobenz(cd)indol-6-yl)-,(R)
6-Acetyl-4-(di-n-propylamino)-1,3,4,5-tetrahydrobenz(c,d)indole
C19H26N2O

Biological Activity

[Description]:

LY 293284 is a potent and selective 5-HT1A receptor agonist. LY 293284 results in a significant drop in core temperature and consumes more food in cholestasis rat induced by bile duct resection[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Marona-Lewicka D, et al. Aripiprazole (OPC-14597) fully substitutes for the 5-HT1A receptor agonist LY293284 in the drug discrimination assay in rats. Psychopharmacology (Berl). 2004;172(4):415-421.  

[2]. Burak KW, et al. Increased midbrain 5-HT1A receptor number and responsiveness in cholestatic rats. Brain Res. 2001;892(2):376-379.  

Chemical & Physical Properties

[ Density]:
1.11g/cm3

[ Boiling Point ]:
478.2ºC at 760mmHg

[ Molecular Formula ]:
C19H26N2O

[ Molecular Weight ]:
298.42

[ Flash Point ]:
243ºC

[ Exact Mass ]:
298.20500

[ PSA ]:
36.10000

[ LogP ]:
3.95970

[ Vapour Pressure ]:
2.63E-09mmHg at 25°C

[ Index of Refraction ]:
1.595