MK-8189

Names

[ CAS No. ]:
1424371-93-6

[ Name ]:
MK-8189

Biological Activity

[Description]:

MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Neurological Disease

[Target]

PDE10A:29 pM (Ki)


[In Vivo]

MK-8189 (0.25-0.75 mg/kg; po) 以剂量依赖的方式减弱大鼠的运动活动。 Animal Model: Male Wistar-Hannover rats[1] Dosage: 0.25, 0.5, and 0.75 mg/kg Administration: Oral administration Result: Improved identification ability relative to the vector handling animal.

[References]

[1]. Layton ME, et, al. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. J Med Chem. 2023 Jan 26;66(2):1157-1171.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H22N6OS

[ Molecular Weight ]:
382.48

Related Compounds