Rabacfosadine succinate

Names

[ CAS No. ]:
1431856-99-3

[ Name ]:
Rabacfosadine succinate

[Synonym ]:
GS-9219 succinate
UNII-3L28LG748I
L-Alanine,N,N'-(((2-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis-,diethyl ester,succinic acid salt (1:1)

Biological Activity

[Description]:

Rabacfosadine (GS-9219) succinate, a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Reiser H, et al. GS-9219--a novel acyclic nucleotide analogue withpotent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma.Clin Cancer Res. 2008 May 1;14(9):2824-32.  

[2]. De Clercq E. Tanovea® for the treatment of lymphoma in dogs. Biochem Pharmacol. 2018 Aug;154:265-269.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H41N8O10P

[ Molecular Weight ]:
644.61400

[ Exact Mass ]:
644.26800

[ PSA ]:
269.75000

[ LogP ]:
1.95310

Related Compounds