GnRH Associated Peptide (1-24), human

GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site[1].

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor

Research Areas >> Endocrinology

GAP (10 nM; 4 h) stimulates the release of both gonadotropins in anterior pituitaries from female Sprague-Dawley rats, but inhibits the basal secretion of prolactin by ~50%, compared with inhibition levels reported for dopamin, a known prolactin-inhibiting factor[2]. GAP (0.1-10 nM; 3-4 h) inhibits prolactin secretion by 40-45%, with an IC50 value of 0.25 nM[2].