Antibacterial agent 130

Names

[ CAS No. ]:
1502721-60-9

[ Name ]:
Antibacterial agent 130

Biological Activity

[Description]:

Antibacterial agent 130 is a 1,1-diarylthiogalactoside, used for targeting the Pseudomonas aeruginosa LecA. Antibacterial agent 130 shows high affinity toward LecA (Kd=1 μM). Antibacterial agent 130 has antibiofilm activity, but lacks bactericidal activity. LecA, a lectin and virulence factor from Pseudomonas aeruginosa involved in bacterial adhesion and biofilm formation[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Antibacterial agent 130 (化合物 8a) (0.08-5 mM; 2-24 h) 剂量依赖性抑制细菌生物膜的形成，在 5 mM 剂量下的抑制率是 100%[1]。 Antibacterial agent 130 (0.01-5 mM; 24 h) 浓度高于1.25 mM 时对 MRC-5 细胞系 (人胎儿肺成纤维细胞) 有细胞毒性[1]。

[References]

[1]. Bruneau A, et al. Discovery of potent 1,1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties. Eur J Med Chem. 2022 Dec 15;247:115025.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H28O10S

[ Molecular Weight ]:
496.53

Related Compounds