tert-Butyl pent-4-yn-1-ylcarbamate

Names

[ CAS No. ]:
151978-50-6

[ Name ]:
tert-Butyl pent-4-yn-1-ylcarbamate

[Synonym ]:
tert-butyl N-pent-4-ynylcarbamate

Biological Activity

[Description]:

N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[References]

[1]. Yang J, et al. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. J Med Chem. 2019 Oct 21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₇NO₂

[ Molecular Weight ]:
183.24700

[ Exact Mass ]:
183.12600

[ PSA ]:
41.82000

[ LogP ]:
2.12890

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Hazard Codes ]:
C

[ RIDADR ]:
UN 2735PSN1 8 / PGII

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%