4-Methoxy(2H4)benzoic acid

Names

[ CAS No. ]:
152404-46-1

[ Name ]:
4-Methoxy(2H4)benzoic acid

[Synonym ]:
2,2'-Bipyridine,4-methoxy
4-Methoxy-2,2'-dipyridiyl
Benzoic-2,3,5,6-d acid, 4-methoxy-
4-Methoxy(H)benzoic acid
4-Methoxy-2,2'-bipyridyl
4-Methoxy-2,2'-dipyridyl

Biological Activity

[Description]:

p-Anisic acid-d4 is the deuterium labeled p-Anisic acid[1]. p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties[2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. DeWeerd K, et al. Metabolism of the 18O-methoxy substituent of 3-methoxybenzoic acid and other unlabeled methoxybenzoic acids by anaerobic bacteria. Appl Environ Microbiol. 1988 May;54(5):1237-42.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
278.3±13.0 °C at 760 mmHg

[ Molecular Formula ]:
C8H4D4O3

[ Molecular Weight ]:
156.172

[ Flash Point ]:
115.5±13.3 °C

[ Exact Mass ]:
156.072449

[ PSA ]:
46.53000

[ LogP ]:
1.96

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.546

Synthetic Route

Click to get detail synthetic route

Related Compounds