RLH-033

Names

[ CAS No. ]:
157097-10-4

[ Name ]:
RLH-033

[Synonym ]:
2-(4-phenylpiperidin-1-yl)ethyl 1-(4-nitrophenyl)cyclopentane-1-carboxylate hydrochloride
2-(4-Phenylpiperidinyl)ethyl 1-(4-nitrophenyl)cyclopentanecarboxylate hydrochloride
Rlh 033

Biological Activity

[Description]:

RLH-033 is a potent and selective ligand for the sigma 1 recognition site. RLH-033 has high affinity for sigma 1 sites labeled by [3H](+)-pentazocine with a Ki of 50 pM[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Signaling Pathways >> GPCR/G Protein >> mAChR
Research Areas >> Neurological Disease

[References]

[1]. R L Hudkins, et al. RLH-033, a novel, potent and selective ligand for the sigma 1 recognition site. Eur J Pharmacol. 1994 Dec 12;271(1):235-6.  

Chemical & Physical Properties

[ Boiling Point ]:
571.5ºC at 760 mmHg

[ Molecular Formula ]:
C25H31ClN2O4

[ Molecular Weight ]:
458.97800

[ Flash Point ]:
299.4ºC

[ Exact Mass ]:
458.19700

[ PSA ]:
75.36000

[ LogP ]:
6.09250

[ Vapour Pressure ]:
4.54E-13mmHg at 25°C