SARS-CoV-2-IN-15

Names

[ CAS No. ]:
1580-42-3

[ Name ]:
SARS-CoV-2-IN-15

Biological Activity

[Description]:

SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[References]

[1]. Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H9ClF3NO2

[ Molecular Weight ]:
315.67

Related Compounds