AK 295

Names

[ Name ]:
AK 295

[Synonym ]:
AK 295
Cbz-leu-abu-conh(CH2)3-mpl
CX 295
Cbz-leu-aminobutyrate-conh(CH2)3-morpholine

Biological Activity

[Description]:

AK 295 (CX 295) is a calpain inhibitor that inhibits apoptosis through a calpain-dependent pathway. AK 295 improves neurological function in a rat model of spinal cord injury (SCI). AK 295 can be used in the study of neurodegenerative diseases, such as bulbar amyotrophy, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

Research Areas >> Neurological Disease

[Target]

Calpain[1].

[References]

[1]. Colak A, et al. Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats. Neurocirugia (Astur). 2009 Jun;20(3):245-54.

Chemical & Physical Properties

[ Density]:
1.145g/cm3

[ Molecular Formula ]:
C₂₆H₄₀N₄O₆

[ Molecular Weight ]:
504.62

[ Exact Mass ]:
504.29500

[ PSA ]:
133.05000

[ LogP ]:
3.00340

[ Index of Refraction ]:
1.524