Metallo-β-lactamase-IN-8

Names

[ CAS No. ]:
1610537-25-1

[ Name ]:
Metallo-β-lactamase-IN-8

Biological Activity

[Description]:

Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC50s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Li JQ, et, al. Hydroxamic acid with benzenesulfonamide: An effective scaffold for the development of broad-spectrum metallo-β-lactamase inhibitors. Bioorg Chem. 2020 Dec;105:104436.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H11ClN2O4S

[ Molecular Weight ]:
326.76

Related Compounds