Tanshinol borneol ester

Names

[ CAS No. ]:
1623012-10-1

[ Name ]:
Tanshinol borneol ester

Biological Activity

[Description]:

Tanshinol borneol ester, an angiogenesis stimulator, promoted multiple key steps of angiogenesis through Akt and MAPK signalling pathways. Tanshinol borneol ester has anti-ischemic and anti-atherosclerosis activities[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Research Areas >> Cardiovascular Disease
Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

[Target]

Akt

AMPK


[In Vivo]

Tanshinol borneol ester (DBZ; 0.2, 1, 5 mg/kg; 腹腔给药; 每天; 8 天) 显着增加了血液含量和微血管形成[1]。 Animal Model: C57BL/6 mouse Matrigel plug model[1] Dosage: 0.2, 1, and 5 mg/kg Administration: IP; daily; 8 days Result: Produced significant increases in blood content compared with vehicle control, while no significant increase in haemoglobin content at the highest dose (25 mg/kg). Significantly increased microvessel formation.

[References]

[1]. Sha Liao, et al. Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris.  

[2]. Pu Jia, et al. The anti-atherosclerotic effect of tanshinol borneol ester using fecal metabolomics based on liquid chromatography-mass spectrometry. Analyst. 2016 Feb 7;141(3):1112-20.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H26O5

[ Molecular Weight ]:
334.41

Related Compounds