BCR-ABL-IN-5
Names
[ CAS No. ]:
1795736-60-5
[ Name ]:
BCR-ABL-IN-5
Biological Activity
[Description]:
BCR-ABL-IN-5 (compound II) is a Bcr-Abl kinase (Breakpoint cluster region-Abelson) inhibitor. BCR-ABL-IN-5 inhibits Bcr-AblWT and Bcr-AblT3151 with the IC50 value of 0.014 μM and 0.45 μM, respectively. BCR-ABL-IN-5 has some anti-proliferative activity against leukemic cells[1].
[Related Catalog]:
[Target]
IC50: 6.5 μM (K562)[1].
[In Vitro]
BCR-ABL-IN-5 (compound II) (0-100 mM, 72 hours) can inhibit the proliferation of K562 human leukemia cells[1]. Cell Proliferation Assay[1] Cell Line: K562 human leukemia cell line Concentration: 0-100 μM Incubation Time: 72 hours Result: Inhibited K562 proliferation with an IC50 value of 6.5 μM.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C25H21Cl2N5O2
[ Molecular Weight ]:
494.37