(R)-Linezolid-d3

Names

[ CAS No. ]:
1795786-02-5

[ Name ]:
(R)-Linezolid-d3

[Synonym ]:
Acetamide-d, N-[[(5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-
N-({(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)(H)acetamide

Biological Activity

[Description]:

(R)-Linezolid-d3 ((R)-PNU-100766-d3) is the deuterium labeled (R)-​Linezolid. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Bednarek E, et al. NMR and molecular modeling study, as complementary techniques to capillary electrophoresis method to elucidate the separation mechanism of linezolid enantiomers. J Chromatogr A. 2008 Jun 6;1193(1-2):164-71.

[3]. Clemett D, et al. Linezolid. Drugs. 2000 Apr;59(4):815-27; discussion 828.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
585.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H17D3FN3O4

[ Molecular Weight ]:
340.365

[ Flash Point ]:
307.9±30.1 °C

[ Exact Mass ]:
340.162628

[ LogP ]:
0.30

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.554

Related Compounds