BACE1-IN-11

Names

[ CAS No. ]:
1803952-77-3

[ Name ]:
BACE1-IN-11

Biological Activity

[Description]:

BACE1-IN-11 is a BACE1 inhibitor. BACE1-IN-11 has the BACE1 inhibitory activity with an IC50 value of 72 μM. BACE1-IN-11 can be used for the research of Alzheimer’s disease (AD) [1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Neurological Disease

[Target]

BACE1:72 μM (IC50)


[In Vitro]

BACE1-IN-11(compound 1) has the BACE1 inhibitory activity with an IC50 value of 72 μM[1].

[References]

[1]. Takuya Otani, et al. Macrocyclic BACE1 inhibitors with hydrophobic cross-linked structures: Optimization of ring size and ring structure. Bioorg Med Chem. 2021 Dec 15;52:116517.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H51N5O8S

[ Molecular Weight ]:
641.82

Related Compounds