AChE/BChE/BACE-1-IN-2
Names
[ CAS No. ]:
1877000-20-8
[ Name ]:
AChE/BChE/BACE-1-IN-2
Biological Activity
[Description]:
AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential[1].
[Related Catalog]:
[Target]
IC50: 0.069 μM (hAChE), 0.097 μM (hBACE-1), 0.127 μM (hBChE)[1]
[In Vivo]
AChE/BChE/BACE-1-IN-2 (Compound 4o) (0-10 mg/kg; p.o.) ameliorates cognitive dysfunction against the scopolamine-induced amnesia model in the Y-maze test[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C18H20F2N2
[ Molecular Weight ]:
302.36