Pancreatic lipase/Carboxylesterase 1-IN-1

Names

[ CAS No. ]:
194235-21-7

[ Name ]:
Pancreatic lipase/Carboxylesterase 1-IN-1

Biological Activity

[Description]:

Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of pancreatic lipase (PL) and human carboxylesterase 1A (hCES1A) with IC50 values of 2.13 µM and 0.055  µM against PL and hCES1A[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

IC50: 0.055  µM (hCES1A), 2.13 µM (PL), 6.02 µM (hCES2A)[1]


[References]

[1]. Zhang J, et al. Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1. J Enzyme Inhib Med Chem. 2022 Dec;37(1):629-640.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H44O4

[ Molecular Weight ]:
468.67

Related Compounds