Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine

Names

[ CAS No. ]:
198284-23-0

[ Name ]:
Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine

[Synonym ]:
L-Phenylalanine,L-tyrosylglycyl-L-leucyl

Biological Activity

[Description]:

Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is a blood pressure lowering peptide containing 4 amino acids. Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is an angiotensin-converting Enzyme (ACE) inhibitor. Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine can be used in research of high blood pressure[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[In Vivo]

Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine (1-1000 μg/kg; s.c.) inhibits blood pressure in normotensive and spontaneously hypertensive rats[1]. Animal Model: Adult male SHR and WKY rats[1] Dosage: 1, 10, 100, and 1000 μg/kg Administration: Subcutaneous injection Result: Inhibited blood pressure in a dose-dependent manner.

[References]

[1]. Nurminen MN, et, al. α-Lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Life Sciences. 2000 Mar 10;66(16):1535-43.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₄N₄O₆

[ Molecular Weight ]:
498.57100

[ Exact Mass ]:
498.24800

[ PSA ]:
181.32000

[ LogP ]:
3.94240