Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
Names
[ CAS No. ]:
199807-33-5
[ Name ]:
Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA
[Synonym ]:
Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl) trifluoroacetate (1:1)
Acetic acid, 2,2,2-trifluoro-, compd. with cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-valyl) (1:1)
Biological Activity
[Description]:
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3, with antitumor activity.
[Related Catalog]:
[Target]
αvβ3[1]
[In Vitro]
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is an inhibitor of integrin αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Val) [c(RGDfV); 35 nM] induces disruption of leukemia cell migration and adhesion to leukemia osteoblasts in the 3D and 2D culture systems, affects the leukemia cell cycle and induces apoptosis in leukemia cells[1].
[Cell Assay]
The osteoblasts are cultured in RPMI 1640 medium for 2 days. MV4-11 cells (1.8×105 cells/mL in the 2D culture system and 1×106 cells/mL in the 3D culture system) are co-cultured with leukemia osteoblasts in RPMI 1640 medium. The experiments used two groups: The experimental group received c(RGDfV) (35 nmol/mL) and the control group received an equal volume of phosphate-buffered saline (PBS) only[1].
[References]
[Related Small Molecules]
Cilengitide
|
Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate salt
|
Arg-Gly-Asp-Ser
|
CWHM-12
|
OSU-T315
|
E 7820
|
GLPG 0187
|
Firategrast
|
ATN-161 trifluoroacetate salt
|
Cucurbitacin B
|
Eptifibatide acetate salt
|
iRGD peptide
|
Lifitegrast
|
Zaurategrast
|
Integrin Antagonist 1 (hydrochloride)
Chemical & Physical Properties
[ Molecular Formula ]:
C28H39F3N8O9
[ Molecular Weight ]:
688.653
[ Exact Mass ]:
688.279236