BMS-195270

Names

[ CAS No. ]:
202822-23-9

[ Name ]:
BMS-195270

[Synonym ]:
unii-20um0t170j

Biological Activity

[Description]:

BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

BMS-195270 (3 μM) 在灌注体积为 0.2-1.3 毫升时显著降低了外源性大鼠整体膀胱模型的压力，同时抑制了自发收缩[1]。 BMS-195270 (2.8 mM) 导致秀丽线虫的成虫表现出 Egl-d 表型，以及缓慢或停止的咽部泵动 (Eat) 和不协调的运动 (Unc)[1]。 BMS-195270 抑制 HEK293 细胞对毛囊素受体激动剂卡巴胆碱 (HY-B1208) 的反应，EC50 为 2 μM[1]。 BMS-195270 抑制钙流，即使内源性钙通道被失活，也保留了抑制活性[1]。

[References]

[1]. Fitzgerald K, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2(4):e57.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H9ClF3N3O2

[ Molecular Weight ]:
355.70

[ Exact Mass ]:
355.03400

[ PSA ]:
70.91000

[ LogP ]:
3.60540

Related Compounds