EGFR-IN-55

Names

[ CAS No. ]:
2057423-46-6

[ Name ]:
EGFR-IN-55

Biological Activity

[Description]:

EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFRL858R/T790M:3.9 nM (IC50)

EGFRWT:70 nM (IC50)


[References]

[1]. Shao J, et al. Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M. Bioorg Med Chem. 2020 Oct 1;28(19):115680.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H25Cl2N7O2

[ Molecular Weight ]:
526.42

Related Compounds