3,7-DMF

Names

[ CAS No. ]:
20950-52-1

[ Name ]:
3,7-DMF

[Synonym ]:
3.7-Dimethoxy-flavon
3,7-Dimethoxyflavone
3,7-dimethoxy-2-phenyl-chromen-4-one
3,7-Dimethoxy-2-phenyl-chromen-4-on

Biological Activity

[Description]:

3,7-DMF is an orally active inhibitor of TGF-β1-induced activation of HSCs. 3,7-DMF induces antioxidant genes and quenches ROS away, which can be used to study liver fibrosis[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad

Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad

Research Areas >> Others

[References]

[1]. Hyomin Park , et al. Discovery of 3,7-dimethoxyflavone that inhibits liver fibrosis based on dual mechanisms of antioxidant and inhibitor of activated hepatic stellate cell. Free Radic Biol Med.2023, 204.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₄O₄

[ Molecular Weight ]:
282.29

[ Exact Mass ]:
282.08900

[ PSA ]:
48.67000

[ LogP ]:
3.47720

Safety Information

[ HS Code ]:
2914509090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%